Chao Jiang,1 Jianping Wang,1 and Haidong Lu2
1 Department of Neurology, The Fifth Affiliated Hospital of Zhengzhou University, Henan, Zhengzhou 450052, China
2 Department of Neurology, The People’s Hospital of Jiaozuo City, Henan, Jiaozou 450052, China
Correspondence should be addressed to Jianping Wang, firstname.lastname@example.org
Received 21 March 2012; Accepted 24 June 2012
Academic Editor: Mamede de Carvalho
Copyright © 2012 Chao Jiang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
We examined whether immunological abnormalities can be found in the specimens of four childhood-onset nemaline myopathy (NM) patients without autoimmune diseases. Pathological examination revealed that nemaline rods were found in all specimens. The immunohistochemical results showed that CD4 positive cells and some other cells were gathered among the necrotic muscle fibers. We conclude that immunological abnormalities are present in the specimens of certain childhood-onset NM patients without autoimmune diseases. Further evaluation of the immunological changes is warranted in childhood-onset NM patients.